How does regeneration interact with the destruction of a permanent?

Regeneration specifically interacts with the destruction of a permanent by replacing the destruction event. When a permanent is marked for destruction, regeneration allows that permanent to avoid being sent to the graveyard. Instead, the regeneration effect creates a replacement effect that effectively removes the permanent from being destroyed.

The mechanics of regeneration involve placing a regeneration shield on the permanent, so when a destruction event occurs—such as from lethal damage or a spell that destroys it—the regeneration effect has the opportunity to activate. The result is that rather than being destroyed, the permanent is tapped and any damage marked on it is removed, allowing it to remain in play. This is why the correct answer points to regeneration as a replacement effect for destruction.

In contrast, other choices do not accurately describe the interaction between regeneration and destruction. Preventing damage, entering the owner's hand, or returning the permanent to the battlefield do not occur within the context of a regeneration trigger; they describe different game mechanics or events. Thus, the focus on how regeneration operates directly during a destruction event highlights why it specifically replaces that event rather than providing alternative forms of resolution.